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KMID : 0356919940270080944
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Korean Journal of Anesthesiology
1994 Volume.27 No. 8 p.944 ~ p.949
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Comparison of the Analgesic Duration of Clonidine and Epinephrine Mixture with Teracaine on Saddle Block
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Abstract
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Clonidine, α2 adrenergic agonist, has a vasoconstrictive property like epinephrine when injected into the subarachoid space. Thus duration of anesthesia would be prolonged in regional block. Besides this effects clonidine also produces direct
analgesic
effect at spinal cord level and potentiates the effect of local anesthetics injected into intrathecal space. In this study saddle blocks were induced in sitting position by the intrathecal injection of tetracaine for the perianal procedures. 45
patients
were classified randomly into three groups. In group I (control0 0.5% tetracaine 4 mg (0.8 ml) and normal saline 0.2 ml was injected intrathecally at L4-5 interspace. In group Ⅱ(epinephrine0 epinephrine 0.2 mg (0.2 ml) was added to 0.5%
tetracaine
4 mg
nad in group Ⅲ (clonidine) clonidine 30 μg (0.2 ml) 2as added to tetracaine 4 mg. After intrathecal injections, sensory block level and motor impairment was checked at 5 min and 50 min. the duration of analgesia was defined by the patients who
complain the postoperative pain at the incision site. The results in each group were as follows. Sensory block level was S1 (control), L5 ±1 (epinephrine0 and L5 ± 1 (clenidine0 at 50 min after injections. The duration of analgesia was
significantly
prolonged in epinephrine group (369.6 ± 64.1 min0 and clonidime group (297.9 ± 33.8 min) compared with control group (194.3 ± 18.2 min). The number of patients with motor block was 12 in epinephrine group, 4 in clonidine group and 1 in control
group.
In conclusion, tetracaine plus clonidine 30 μg to prolong the duration of analgesia is considered as adequate and safe dosage without significant adverse effects in saddle block.
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